WebSep 2, 2024 · Here, we review data on cancer/testis (CT) antigens as targets for CAR T-cell therapy and present a strategy to upregulate CT antigen expression on tumor cells via epigenetic treatment to sensitize … WebOct 11, 2009 · Cancer/testis (CT) antigens are protein antigens with normal expression restricted to adult testicular germ cells, and yet are aberrantly activated and expressed …
Cancer/testis antigens - Wikipedia
WebRajagopalan K, Mooney SM, Parekh N, Getzenberg RH, Kulkarni P. A majority of the cancer/testis antigens are intrinsically disordered proteins. J Cell Biochem. 2011;112(11):3256–3267. 13. Fradet Y, Picard V, Bergeron A, Larue H. Cancer-testis antigen expression in bladder cancer. Prog Urol. 2005;15(6 Suppl 1):1303–1313. 14. WebApr 1, 2010 · Cancer/testis antigens (CT antigens) are thought to be suitable targets for antigen-specific immunotherapy, because of the cancer-specific expression except for the testis among various normal tissues and no-expression of HLA class I in the testis. In the present study, the expressions of CT antigens (MAGE-A3, MAGE-A4, NY-ESO-1 and … north face everyday pants
Cancer Testis Antigen - an overview ScienceDirect Topics
WebApr 23, 2024 · Cancer-testis (CT) antigens were identified by their ability to elicit T- or B-cell immune responses in the autologous host. They are typically expressed in a wide … WebJan 1, 2003 · Cancer/testis antigens are expressed in various malignant tumors, but not in normal adult tissues, except for testicular germ cells and occasionally placenta ().CT … Cancer/testis (CT) antigens are a group of proteins united by their importance in development and in cancer immunotherapy. In general, expression of these proteins is restricted to male germ cells in the adult animal. However, in cancer these developmental antigens are often re-expressed and can serve as a … See more With the development of tumor-associated antigens (TAA), the first clone of a human tumor antigen, melanoma antigen-1 (MAGE-1) was reported in 1990s, which elicited an autologous cytotoxic T-lymphocyte (CTL) … See more Germ cells share some features with cancers. The motile and penetrating features and colonization of primitive germ cells resemble the … See more Immunogenicity In normal tissues, CT antigens are exclusively expressed in testis, making it no access to the immune system. Besides, the existence of blood-testis barrier and the lack of human leukocyte antigen (HLA) class I expression … See more CT antigens can be divided by whether they are encoded on the X chromosome (X-CT antigens genes) or not (non-X-CT antigens genes). It … See more The expression of CT antigens genes are exclusively regulated by epigenetic events both in normal and cancer tissues, while DNA methylation and histone post-translational modification remain the most widely characterized epigenetic factors here. See more north face etip recycled gloves