Gata-3 breast cancer

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August undefined, 2024

WebJul 1, 2012 · GATA3 (GATA binding protein 3 to DNA sequence [A/T]GATA[A/G]) is 1 of 6 members of a zinc finger transcription factor family, and it plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types, 1, 2 including luminal glandular epithelial cells of the mammary gland, 3–5 … WebThe protein expression data is derived from antibody-based protein profiling using immunohistochemistry. A summary of RNA categories for human tissues, cell lines and cancer tissues. Categories for RNA specificity include tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.

GATA3: A promising marker for metastatic breast …

WebMar 9, 2012 · A GATA3 mutant cell line is developed by CRISPR which endogenously expresses a heterozygous R330 frame-shift (R330fs) mutant, which induces transcriptional reprogramming in T47D luminal breast cancer cells leading to more aggressive phenotypes such as faster tumor growth. GATA3 has been identified as one of the most frequently … WebDec 15, 2005 · GATA binding protein 3 (GATA3), a transcriptional activator, emerged as one of the top genes with low expression in the meta-signature. In breast cancer, high … german shepherd wolf mix lifespan

Shift in GATA3 functions, and GATA3 mutations, control …

WebNational Center for Biotechnology Information WebJun 1, 2009 · GATA-3 expression in breast cancer has a strong association with estrogen receptor but lacks independent prognostic value. Cancer Epidemiol Biomarkers Prev 17 : 365–373. Article CAS Google Scholar WebA recent study found GATA-3 to be associated with favorable breast cancer pathologic features, including negative lymph node and positive estrogen receptor (ER) … german shepherd with vest

GATA3 expression in primary lung carcinomas: correlation with ...

WebJun 1, 2009 · GATA-3 expression in breast cancer has a strong association with estrogen receptor but lacks independent prognostic value. Cancer Epidemiol Biomarkers Prev 17 … WebJan 11, 2024 · Immunohistochemical stains (IHC) are often used for work-up of carcinoma of unknown primary, and in this context, coexpression of CK7, GATA3, and ER is highly … christmas at rainbow bridgeWebDec 9, 2024 · α5(IV) collagen is expressed in luminal breast cancer and regulates breast cancer cell proliferation. (A) Heatmap of Pearson's correlation coefficient of BM components (green font: major α1(IV) and α2(IV); red font: minor α5(IV)), breast cancer subtype scores (purple font), and luminal breast cancer key transcription factors ERα and GATA-3 (blue … christmas at radio city

"WebDec 1, 2011 · GATA3 inhibits lysyl oxidase-mediated metastases of human basal triple-negative breast cancer cells. Chu IM et al: 19084267: 2009: The significance of GATA3 expression in breast cancer: a 10-year follow-up study. Ciocca V et al: 19483726: 2009: GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. … " - Gata-3 breast cancer

Gata-3 breast cancer

WebThe Novel Marker GATA3 is Significantly More Sensitive Than Traditional Markers Mammaglobin and GCDFP15 for Identifying Breast Cancer in Surgical and Cytology … WebDec 1, 2024 · Mutation of GATA3 in breast cancer was discovered before the advent of large-scale sequencing studies [23]. Genomic sequencing projects have indicated that GATA3 is mutated with high frequency in breast cancer, with 10–15% of breast tumors harboring GATA3 mutation [9, 10]. The majority of GATA3 mutations are found in …

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WebJan 24, 2024 · 1. Introduction. GATA binding protein-3 (GATA3) is a transcription factor that regulates cell differentiation and is thought to be a sensitive biomarker for carcinomas of breast and urothelial origins [1].However, GATA3 expression is not specific to these sites and can be seen in other normal and neoplastic tissues, including tumors originating …

WebStudies have shown that GATA3 has a critical role in the development of epithelial structures in both embryonic and adult tissues. The majority of studies regarding GATA3 expression in tumor evaluation focused on breast and urothelial neoplasms, whether primary or metastatic. Its sensitivity in these neoplasms has been reported to be high and ... WebJun 23, 2009 · The expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3) are expressed in close association with ERα, both encoding for transcription factors with a …

WebGATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with estrogen receptor-alpha expression in breast cancer … WebGATA-3 b regulates luminal epithelial cell differentiation in the mammary gland, is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA-3 is one of the three genes mutated in 10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ ...

WebGATA3 is one of the three genes mutated in >10% of breast cancers (Cancer Genome Atlas). Studies in mice indicate that the gene is critical for the normal development of …

WebThe GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. GATA3 in particular is necessary for mammary gland maturation, and its loss has been implicated in breast cancer development. Our goal was to validate the ability of GATA3 expression to predict survival in breast cancer patients. german shepherd wolf mix for saleWebNov 20, 2014 · GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in basal-like breast cancers. Here, we focused on its function in luminal breast cancer, where GATA3 is … christmas at pudding hallWebFeb 1, 2016 · 1. Introduction. GATA3 is 1 of 6 members of the GATA family of transcription factors, whose members contain zinc-finger DNA binding domains that bind to consensus 5′- (A/T) GATA (A/G)-3′ motifs [1], [2]. The family members, GATA1-6, play a wide role in determination of cell differentiation and control of cell proliferation and movement [1]. german shepherd with wolf