Witryna15 kwi 2024 · Hepatocellular carcinoma (HCC) has an increasing incidence and dismal prognosis, with few systemic treatments approved, including several small molecule tyrosine kinase inhibitors. Witryna4 kwi 2024 · A novel small molecule inhibitor of ENPP1 promotes T and NK cell activation and enhances anti-tumor efficacy in combination with immune checkpoint blockade therapy [abstract].
RRx-001, a first-in-class small molecule inhibitor of MYC and a ...
Witryna10 kwi 2024 · New agents approved in the United States for the treatment of CRC, including targeted agents, immunotherapy, and small molecule agents. Skip to navigation Skip to main content. Menu Close. WitrynaSmall molecule PD-1/PD-L1 inhibitors and STING activators are still in a premature state and their decisive application needs to wait for the ongoing clinical outcomes. Since no small molecule immunotherapy has been approved yet, the future research should continue to focus on discovery of novel small molecules with distinct chemo-types … how is the violin made
KRAS mutation & non-small cell lung cancer OTT
WitrynaIn this latter company, the Translational Medicine team I've built and managed for almost 5 years is successfully supporting the clinical development of 2 immuno-oncology drugs: A2AR inhibitor (small molecule) and aTIGIT antibody (6 phase I/II clinical trials). Since May 2024, I lead R&D operations at Aelin Therapeutics, a biopharmaceutical ... Witryna27 kwi 2024 · Programmed death-1/programmed death ligand-1 (PD-1/PD-L1) based immunotherapy is a revolutionary cancer therapy with great clinical success. The majority of clinically used PD-1/PD-L1 inhibitors are monoclonal antibodies but their applications are limited due to their poor oral bioavailability and immune-related … WitrynaWe have written this Point-of-view article to clarify the main mechanism of action of RRx-001, a pharmaceutically unprecedented sui generis Phase 3 small molecule that is derived from the aerospace industry. RRx-001 has demonstrated anticancer activity through antiangiogenic, immune, epigenetic, antioxidant, apoptotic and nitric oxide … how is the violin hard to play