Randle hypothesis
Webb20 aug. 2024 · Many researchers have invoked the Randle hypothesis to explain the reduced glucose disposal in skeletal muscle by envisioning an elevated acetyl CoA pool arising from increased oxidation of fatty acids. Over the years, in vivo NMR studies have challenged that monolithic view. Webb15 juni 2024 · In 1963, Randle et al. 3 stated that “several abnormalities of carbohydrate metabolism in many disorders, including diabetes, are associated with high circulating FA levels”. This observation was the starting point for investigating the role of FA in the development of IR.
Randle hypothesis
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Webb1 dec. 1990 · A hypothesis is presented that addresses the etiology of diabetes in the obese. Evidence from many areas of research suggests that ready availability of free fatty acids for oxidation by muscles and other tissues may lead to impairment of carbohydrate oxidation and lead to glucose intolerance as is seen in obesity and obese diabetics. WebbThese observations appear to conflict with the Randle hypothesis (the glucose-fatty acid cycle) and raise some doubt as to whether plasma FFA concentrations are direct determinants of glucose or IRI concentrations in normal man.
Webb4 dec. 2014 · native hypothesis that accumulation of an intracellular lipid metabolite mediates insulin resistance associated with obesity and type 2 diabetes by causing … WebbThe glucose-fatty acid cycle (Randle hypothesis) This hypothetical mechanism is based on the concept that FFA compete with glucose for mitochondrial oxidation (glu-cose-fatty …
The Randle cycle, also known as the glucose fatty-acid cycle, is a metabolic process involving the competition of glucose and fatty acids for substrates. It is theorized to play a role in explaining type 2 diabetes and insulin resistance. It was named for Philip Randle, who described it in 1963. Visa mer The Randle cycle is a biochemical mechanism involving the competition between glucose and fatty acids for their oxidation and uptake in muscle and adipose tissue. The cycle controls fuel selection and adapts the … Visa mer The impairment of glucose metabolism by fatty acid oxidation is mediated by the short-term inhibition of several glycolytic processes. The extent of inhibition increases along the … Visa mer Malonyl-CoA signals glucose utilization and it controls the entry and oxidation of long-chain fatty acids (LCFA) in the mitochondria. Circulating glucose in the liver stimulates its uptake. Glucose oxidation produces citrate which can be converted to malonyl … Visa mer Fasted state When fasting, the activation of lipolysis provides fatty acids as the preferred fuel source for respiration. In the liver β-oxidation of fatty acids fulfills the local energy needs and may lead to ketogenesis (creating Visa mer Hemodynamic stress overrides fatty acid inhibition of glucose metabolism. During this time there is a decrease in substrate supply and an … Visa mer Malonyl-CoA concentration The concentration of malonyl-CoA depends on the balance between acetyl-CoA carboxylase (ACC) and malonyl-CoA decarboxylase … Visa mer Fatty acids are preferentially oxidized because of the inactivation of PDH by fatty acid oxidation inhibiting glucose oxidation. This suggests that mitochondrial metabolism may … Visa mer Webb1 juni 2004 · According to Randle , the essential components of this hypothesis are 1) that the relationship between glucose and FFA metabolism is reciprocal, 2) that in vivo and …
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Webb6 mars 2024 · A hypothesis (plural hypotheses) is a precise, testable statement of what the researcher (s) predict will be the outcome of the study. It is stated at the start of the … intj\u0027s crush typeWebb14 feb. 2013 · The article by Keung et al. in this issue of Diabetes revisits the Randle hypothesis of a reciprocal relationship between fat and glucose oxidation. Inhibition of mitochondrial entry of fatty acids by oxfenicine resulted in improved glucose tolerance and insulin sensitivity in high-fat diet–fed mice, while body mass was maintained. new launch property in genting highlandWebbhypothesis • We hypothesize that children who read for 15 minutes or more per day with a parent will score significantly higher on kindergarten reading assessment than children … int judge int a int b