WebJun 28, 2024 · TDP-43 mediates proper Stathmin-2 (STMN2) mRNA splicing, and STMN2 protein is reduced in the spinal cord of most patients with amyotrophic lateral sclerosis (ALS). To test the hypothesis that STMN2 loss contributes to ALS pathogenesis, we generated constitutive and conditional STMN2 knockout mice. ... ALS is a … WebSep 14, 2024 · STATHMIN-2 is a well-known protein important for neural repair and axonal stability, the expression of which is significantly decreased in the majority of ALS patients. …

Is Stathmin-2 the Next Piece of the ALS Jigsaw Puzzle?

WebALS is a devastating neurodegenerative disease in part characterized by TDP-43 dysfunction, which has been recently implicated in the loss of Stathmin-2 (STMN2), a protein critical for neuronal process outgrowth and maintenance of the neuromuscular junction. TDP-43 dysfunction occurs in greater than 90% of all ALS patients, WebHappy to anounce that the first patient has been dosed with our ASO targeting misplicing of #Stathmin2 in #ALS patients! duraphat varnish 22 600

Hagen Cramer on LinkedIn: #stathmin2 #als

WebMay 5, 2024 · Stathmin 2 is highly expressed in motor neurons and necessary for normal axonal maintenance and health. The presence of altered Stathmin-2 may be a proxy for the TDP-43 pathology that occurs in about half of all individuals with FTD and the majority of individuals with ALS. WebDec 7, 2024 · "STATHMIN-2 is a well-known protein important for neural repair and axonal stability, the expression of which is significantly decreased in nearly all ALS patients. TDP-43 is an RNA binding ... WebMar 28, 2024 · The stathmin-2 protein is known to play roles in providing structural support to nerve cells and axons — the long fibers that nerves use to connect with each other. The researchers showed that motor neuron cells lacking stathmin-2 … crypto beurs nederland