WebApr 6, 2024 · About STATHMIN-2 and TDP-43 STATHMIN-2 (STMN2) is a well-validated protein important for neural repair and axonal stability, the expression of which is significantly decreased in nearly all ALS ... WebStathmin is a ubiquitously expressed microtubule destabilizing phosphoprotein that is upregulated in a number of cancers. The amino terminus of the protein contains multiple …
Recombinant Anti-Stathmin 1 (phospho S63) antibody [EPR1574 ... - Abcam
WebMar 29, 2024 · Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be … WebStathmin is an intracellular phosphoprotein that controls the microtubule dynamics by further regulating proper attachment and alignment of chromosomes in a dividing cell. Thus, any mutation or aberrantly expressed protein that reduces the fidelity of spindle assembly will enhance chromosomal instability contributing to aneuploidy. Oral ... michigan\u0027s offensive coordinator
Stathmin expression associates with vascular and immune
WebApr 11, 2024 · Stathmin 1 acts as a microtubule destabilizer by interacting with αβ-tubulin heterodimers and inhibiting microtubule polymerization. Stathmin 1 has two functional domains: The N-terminus domain facilitates microtubule depolymerization, and the C-terminus domain is indispensable for tubulin dimer binding and sequestering [ 12 ]. WebNov 27, 2013 · Stathmin's sequestration activity is now well documented (3, 4), but the issue of whether stathmin acts directly on MTs has proven difficult to resolve.In particular, one would predict that for stathmin to directly induce catastrophe, it must interact with microtubule polymer, but thus far published reports have shown that binding of stathmin … WebJun 19, 2024 · This deleterious effect on stathmin was abrogated by treatment with AMD3100 (Supplementary Data Fig. S2b), a compound that antagonizes the gp120 interaction with its chemokine coreceptors. 2 The ... michigan\u0027s oldest city